dermatophagoides farinae alergia

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dermatophagoides farinae alergia

Category : Sin categoría

De nombreuses personnes sont allergiques aux acariens de poussière de maison (Dermatophagoides pteronyssinus, Dermatophagoides farinae ou Blomia tropicalis). Other associations were observed in the pro-inflammatory cytokines IL1A−889 (T/T, C, and T) and IL2−330 (G/T and T/T) and the anti-inflammatory cytokines IL4RA+1902 (A and G), IL4−590 (T/C, T/T, C, and T), and IL10−592 (A/A, C/A, A, and C). Ils sont connus pour être l'une des causes les plus fréquentes d'allergie. The most common side effects of these skin tests are itching and redness. À noter : chez un enfant, il est important de traiter la rhinite allergique aux acariens à son début pour éviter le risque de complication en asthme chronique (70 % des cas). The Mexican guideline of immunotherapy dates from 1998. The majority of mites (91.6%) was. Objective: To assess sensitization of allergic patients to different mite species in the Cuban city of Camaguey; as well as to compare standardized allergen extracts from different sources by skin prick tests. In Mexico there have been few studies to investigate sensitization to this mite. The mite family Pyroglyphidae had the highest, Background: House dust mites are important airborne allergens worldwide, particularly in the tropical environment. Acari were found in 50 (37.3%) of 134 samples from the flats, in 11 (15.5%) of 71 samples from the hospitals and in 13 (18.1%) of 72 samples from the hotels. Un grand nombre d’entre eux sont des enzymes. À l'intérieur de la maison, leurs niches préférées sont la literie (matelas, couvertures, oreillers) où les conditions sont les plus favorables à leur développement, mais on les trouve aussi en grande quantité dans les tapis, les moquettes, les canapés, les rideaux, les peluches... Ils ne piquent pas et sont inoffensifs pour l'homme, mais leur carapace et leurs déjections contiennent plusieurs protéines allergisantes, comme le Der P1. molecular assay of major allergens is advantageous in deciding and/or modifying the decision to initiate sIT in children with clinical indication which are sensitized to Dermatophagoides pteronyssinus. Se brosser les dents naturellement dès 6 ans, Conjonctivite allergique - Adulte et enfant, Rhinite allergique saisonnière, conjonctivite, urticaire, Traitement des allergies - A partir de 6 ans, Lun au Ven 8h30/12h30 - 14h/19h - Sam 9h à 12h30. Ce sont les acariens domestiques les plus répandus en Europe. We studied 587 asthmatic patients, residents in Quito, Ecuador, (2800 m above sea, Introduction A total of 88.4% of patients were positive to D. siboney, 87.1% to D. pteronyssinus, and 68.1% to B. tropicalis. Extracts of these mites may provide a more accurate diagnosis and effective treatment of respiratory diseases due to mite allergy in Israel and probably in other countries with similar climes. J Investig Allergol Clin Immunol. Ces cookies permettent d’interagir depuis le site VIDAL avec les modules sociaux et de partager les contenus du site du avec d’autres personnes, lorsque vous cliquez sur le module "Partager", de Facebook et de Twitter, par exemple. Get the latest research from NIH: https://www.nih.gov/coronavirus. Skin tests with L. destructor were positives in 109 patients (65,7%) and with T. putrescentiae in 78 patients (47%). Correlations of r = 0.45, 0.45 and 0.68 (statistically significant, p < 0.05) were found between the three species of Dermatophagoides, while there was no correlation between positive dermoreactions of Blomia tropicalis with those of Dermatophagoides. Background: Several international guidelines on immunotherapy exist, but they only apply partially in Mexico. Introduction Ces acariens peuvent parfois contaminer la nourriture (en particulier les farines et les produits à base de farine) et provoquer des réactions d'allergie alimentaire parfois sévères. The correlation between DF and DP sensitization was higher than the correlation between DF or DP to BT (r = .78 versus r = .60, p < .05). Your doctor or nurse observes your skin for signs of allergic reactions after 15 minutes. In United States, Blomia tropicalis has the fourth place between the most known types of house dust mites, and is the most common in the southern subtropical states. Le diagnostic d'allergie aux acariens peut être confirmé par un test cutané (prick-test). Resumen Antecedentes: El papel del diagnóstico molecular en la alergia a los ácaros no ha sido estudiado en profundidad. On the other hand, with Biocen extracts, the highest positivity was noted in Dp and D. siboney (Ds). Elle peut, à la longue, se compliquer de crise d'asthme et/ou plus rarement d'eczéma. Les antigènes majeurs sont Der pl (Dermatophagoïdes pteronyssinus), Der fi (Dermatophagoïdes farinae), Eur ml (Euroglyphus maynei). Concrètement, l'homéopathie va soigner une personne souffrant de nausées par l'ingestion d'un vomitif. Les dermatophagoides pteronyssinus sont une espèce de minuscules acariens qui pullulent à l'intérieur de nos maisons. J Investig Allergol Clin Immunol. Sensitization of 117 patients with persistent rhinitis who attended the Allergy and Asthma Center in Tel Aviv (Israel) was evaluated by a skin prick test (SPT) using standardized allergenic extracts. These side effects usually go away within 30 minutes. Our purpose was to analyze the relationship between asthma and sensitization to the house-dust mites D. pteronyssinus and D. farinae in Andean altitudes. Dedicated research and development and manufacturing facilities certified to ISO 13485:2016. The increased prevalence of asthma has been associated with an increase in atopic sensitization, and it is parallel with similar increases in other allergic diseases. Blo t 21 was initially identified from an expressed sequence tag database generated from a B tropicalis cDNA library. There were positive skin tests with mites in 59% of the patients, 24.5% for Blomia t; 10% for D. pteronyssinus plus Blomia t. and 7.29% for D. farinae plus Blomia t. The correlation of the skin reactivity between Dermatophagoides pteronyssinus and Blomia tropicalis (r= 0.36) and between Dermatophagoides farinae and Blomia tropicalis (r= 0.27), was not significant in both cases. Elle se définit comme soignant « le mal par le mal » (homéo signifie semblable en grec ancien, et pathie vient de pathos, qui signifie ce qu'on éprouve, ce qui affecte, la maladie). NIH 1) positive prick-test to Dermatophagoides pteronyssinus; and 2) clinically relevant disease under treatment. des bronchodilatateurs, pour favoriser la dilatation des bronches. Dermatophagoides pteronyssinus (Trouessart, 1897) Invest every year in numerous scientific study partnerships, research consortia, scientific symposia, and education materials. Overview. Although the majority (>75%) of sensitized individuals were cosensitized to both Blo t 5 and Blo t 21, these 2 allergens had a low-to-moderate degree of cross-reactivity. [Article in Spanish] Sánchez Medina M, Mulla MS, Charlet LD, Correa C, Molina AR. Dedicated application laboratory for support with discrepant results.Â. In Germany, 4.5 millions of the general population are showing symptoms such as rhinitis or asthma caused by an allergy to house dust mites. To identify the prevalence of sensitization to Blomia tropicalis and Dermatophagoides in patients with rhinitis and/or allergic bronchial asthma in a population of the metropolitan area of Mexico. However, sera of 494 consecutive individuals attending outpatient allergy clinics over 1(1/2) years showed 57.9% (286/494) had positive responses to Blo t 21. This study aims to investigate the characteristics of co-sensitization and the IgE cross-reactivity among them and attempts to identify whether patients are sensitized to Blo t due to cross-reaction or true sensitization. Secondary objectives were to correlate potential sensitization to Blomia with sensitization to Lepidoglyphus destructor and Tyrophagus putrescentiae. A total of 232 adult patients with asthmatic symptoms caused by house dust and positive SPT to at least one mite were included. 1997 Jan-Feb;7(1):46-50. Aceste tipuri de alergie sunt răspândite ubicuitar, iar prevalenţa lor este în continuă creştere1. p > 0.05). Of 4,152 mites detected in bedrooms, 1,330 (32%) were isolated from 31 spring mattresses and 2,822 (68%) from 6 woolen mattresses (P < 0.001). En désactivant ces cookies, vous ne pourrez plus partager les articles depuis le site VIDAL sur les réseaux sociaux. In the metropolitan area of Mexico City, while not having a tropical or sub-tropical weather, it is important to include Blomia tropicalis in diagnostic panels of allergens. Conclusions: Dust samples were taken from a total of 53 houses in 2013- Blo t 21 is a major allergen in B tropicalis that is not highly cross-reactive to Blo t 5, despite sharing some sequence and structural identity. Lepidoglyphus destructor. Dermatophagoïdes farinae dose peut être pris en 5 différentes dilutions. This study has established valuable information about the co-sensitization and cross-reactivity of Blo t with two Dermatophagoides species (Der p and Der f) and helps to provide adequate diagnosis and treatment of the mite-allergic patients. Dermatophagoides farinae (Hughes, 1961) Habitat: Very common, and abundant in the home (carpets, mattresses...). Get the latest public health information from CDC: https://www.coronavirus.gov. Consulter la notice en cliquant ici si le PDF ne s'affiche pas. Inclusion criteria: Asthma and its relation with Dermatophagoides pteronyssinus and Dermatophagoides farinae in Andean altitudes (Quito, Ecuador). Differences between patients and controls utilizing SPT results was statistically significant, but not when using mite-specific IgE results. Case records of patients with chronic idiopathic urticaria who underwent skin prick testing during the years 2000 to 2007 were reviewed. Le médecin pique légèrement la peau au travers de chaque goutte pour introduire la substance au niveau de l'épiderme. The clinical files of 279 patients. Dermatophagoides farinae and Musca domestica was also significant with skin test (correlation coefficient 0.362, P<0.05) and RAST (correlation coefficient 0.363, P<0.05), but it was not such a high correlation as house dust. We evaluated whether Blo t 21 and Blo t 5 were cross-reactive by using IgE inhibition ELISAs. The most important House dust mites are Dermatophagoides pteronyssinus and (in drier areas) D. farinae.In subtropical and tropical regions the Storage mite Blomia tropicalis is also a major source of allergens, co-existing with D. pteronyssinus.Recent evidence shows that even these very general boundaries are blurring, and in … The total number of patients who presented positive skin test to Blomia tropicalis in association with other mites was 53 (28.0%) and the total number of patients who presented positive skin test to only Blomia tropicalis was 23 (12.1%). Il s’agit d’animaux microscopiques, invisibles à l’œil nu, mesurant de 0,2 à 0,5 mm. Skin-prick tests with D. pteronyssinus and D. A dose correlation was obtained between house dust and Dermatophagoides farinae with skin test (correlation coefficient 0.871, P<0.005) and RAST (correlation coefficient 0.575, P<0.005). MMW Fortschr Med. The study identified 14 families, 17 genera, and 16 species belonging to Astigmata, Prostigmata, and Oribatida. Methods Accès au chômage partiel et COVID-19 : le Conseil d’État suspend les critères de vulnérabilité du décret du 29 août 2020, Cannabis thérapeutique : publication du décret autorisant l’expérimentation sur la mise à disposition dans 5 indications, L'intelligence médicale au service du soin, * En cliquant sur "Ajouter un commentaire", vous confirmez être âgé(e) d'au moins 16 ans et avoir lu et accepté, Pour recevoir gratuitement toute l’actualité par mail, Bien utiliser ses produits de parapharmacie, Recherche par nom de produit de parapharmacie, les règles et conditions d'utilisation de l'espace participatif "Commentaires". asthma and/or allergic rhinitis and in 60 non-allergic volunteers, ranging from 2 to 76 years old. farninae. Crameri, R (2014). Specificity varied from 72 to 85%. were collected from living rooms and bedrooms of 37 randomly selected houses from various districts of the city. Blo t 21, representing a new group of allergens, is an important B tropicalis allergen. All rights reserved. Correlation between skin tests to Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomia tropicalis in Cuban asthmatics, Sensitization to mites of the genus Blomia in the urban area of Cartagena in Levante, Sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus, farinae and siboney prevalence in patients with rhinitis, allergic asthma, or both, in a population of a metropolitan area of Mexico City, Sensitization to Dermatophagoides , Blomia tropicalis , and Other Mites in Atopic Patients, Identification and characterization of a novel allergen from Blomia tropicalis: Blo t 21, House Dust Mite Species in Ordu Province, Turkey. In both groups, Diater-Prick lancets were used, together with Valergen extracts (Biocen, Cuba) at 20,000 BU/mL and Diater extracts (Argentina) at 50,000 UBE/PNU/mL. To read the full-text of this research, you can request a copy directly from the authors. All patients underwent skin prick tests with allergenic extracts. Der p 1 and Der p 2 are dominant allergens in our population and there may be benefits in determining these molecular allergen levels in patients with a positive prick-test and a clinical indication for sIT prior to a decision of initiating sIT or not. Background: A higher number of Blomia-sensitized patients lived in old and humid homes than non sensitized patients. Assay Der p 1 and Der p 2 values ≥0.35 kUA/L were considered positive. Methods: Statistical significance was set at p < 0.05. Sous nos climats, c'est la variété d'acariens la plus fréquemment rencontrée dans la poussière de la maison (70 à 80 %). Patch test response to house dust mites is positive in children with atopic dermatitis and in their parents. Vaccins contre la COVID-19 : doit-on s'inquiéter du risque de maladie aggravée chez les personnes vaccinées ? Results: Complications rénales d’origine médicamenteuse : comment les prévenir ? level), ranging in age from 8 months to 84 years. Comparison of Living and Bedrooms in Terms of House Dust Mites in the Province of Erzincan, Turkey. We selected 334 patients with a diagnosis of rhinitis and/or bronchial asthma, 149 men and 185 women, aged between 3 and 74 years, of which 189 had positive skin tests to at least one of the mites (Dermatophagoides and/or Blomia tropicalis). Around 85.50% of patients were sensitized to Der p, 85.37% of patients were sensitized to Der f, and 71.54% of patients were sensitized to Blo t. Further, 70.14% of patients were co-sensitized to Blo t, Der p, and Der f, and only seven patients were sensitized solely to Blo t. With increasing sIgE levels for Blo t, the positive rates of severe-level (class 5-6) co-sensitization to Der p or Der f significantly increased. Reaction size was strongly correlated (r = 0.71, p = 5.3 x 10-09) between D. siboney and D. pteronyssinus, whereas no significant correlation was found between D. pteronyssinus or D. siboney and B. tropicalis. Allergen Exposure Geographical distribution. Correlation of skin reactivity between allergenic extracts Dermatophagoides pteronyssinus and Dermatophagoides farinae , with B. tropicalis in patients with allergic rhinitis and asthma. This site needs JavaScript to work properly. The majority of Blomia-sensitized patients also showed positives skin tests with L. destructor and/or T. putrescentiae. Vous pouvez vous opposer à l'utilisation de ces cookies et/ou consentir à l'utilisation de cookies complémentaires (interaction avec les réseaux sociaux) en. Patients with mite-sensitization were more commonly male and more often had a personal or family history of atopy compared with those without mite-sensitization. Conclusion Plus d’une dizaine d’allergènes ont été identifiés. Elle soigne aussi bien les symptômes locaux que les maladies chroniques. With this study, the authors aim to understand the local epidemiology and to clarify if the, 277 samples of house dust collected in 1996-1998 from 17 flats, three hospitals, two hotels and one students' hostel situated in the cities of Gdansk and Gdynia were subjected to acarological examination. Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomia tropicalis are the most important allergenic mites in Cuba. L’acquisition d’une sensibilisation aux acariens est étroitement corrélée à un taux d’antigène Der pi > 2 pg/gramme de poussiè­re de maison. Three hundred and thirty asthmatic patients (56.2%) were sensitized to house-dust mites while only 15 (30%) of the 50 asymptomatic students were sensitized (p < 0.01). Retrospective study with analysis of patients with asthma and/or rhinitis. occurring in all sampled houses in the city of Ordu. We measured the wheal area and compared the averages of the surface of the wheal and correlations were made of the results using the Pearson correlation coefficient. All patients filled a questionnaire with four variables related with home characteristics. It was also greater in the asthmatics with chronic rhinitis than in the group of asthmatics without nasal symptoms (p < 0.01). You can request the full-text of this article directly from the authors on ResearchGate. Allergen-specific immunotherapy (sIT) is the only treatment that improves symptoms, reduces the need for pharmacological therapy and modifies the natural history of the disease. Skin tests with some of the two studied species of Blomia were positives in 76 patients (45,78%) and negatives in 90 (54,22%). Search for consensus on the answers among members of the Regional chapters of both Mexican Colleges of Allergists (CMICA and COMPEDIA) during regional meetings. Der p 1 and Der p 2 was <0.35kUA/L in 29 (10,4%) patients. Ongoing collaboration with the academic and scientific community around the globe. Conclusions: Dermatophagoides pteronyssinus : qu'est-ce que c'est ? Specific IgE (sIgE) in the sera from 1497 allergenic patients was determined by ImmunoCAP. Asthma. Sensitivity values were 78% (Dp); 78% (Ds) and 82% (BT). Key words: Dermatophagoides pteronyssinus. 4–max. Methods Les premiers symptômes d'une allergie aux dermatophagoides pteronyssinus apparaissent souvent le matin au réveil et au cours des périodes froides d'automne ou d'hiver pendant lesquelles les habitations sont plus chauffées et moins aérées. Conclusions Journal of investigational allergology & clinical immunology: official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología. A total of 172 patients were enrolled in the study. Blo t 21, a 129-amino-acid protein sharing 39% identity with Blo t 5, is a product of a single-copy gene. Votre choix quant à l'utilisation et/ou au dépôt de cookies par Vidal et ses partenaires peut être réalisé de manière indépendante pour chacune des finalités listées ci-dessous. Results: The highest values of sensitization prevalence using Diater extracts were seen in Dermatophagoides pteronyssinus (Dp), Dermatophagoides farinae (Df), and Blomia tropicalis (Bt) in allergic patients and in non-allergic controls. © 2008-2020 ResearchGate GmbH. KEYWORDS: Allergen immunotherapy, subcutaneous immunotherapy, sublingual immunotherapy, skin testing, allergy diagnosis, rhinitis, asthma, atopic dermatitis, house dust mite, pollens, anaphylaxis, adrenaline, Mexico. D2-Dermatophaggoides farinae. 95.0% of mites from the flats, 35.0% mites from the hotels and 8.0% mites from the hospitals belonged to two dust mite species of the family Pyroglyphidae: Dermatophagoides pteronyssinus and Dermatophagoides farinae. Ces cookies ne sont pas soumis, en application de l’article 82 de la loi n° 78-17 relative à l'informatique, aux fichiers et aux libertés ainsi qu'à la Délibération n°2020-091 de la CNIL, à votre consentement. ... 6 Some studies have reported a moderate correlation between Der p and Blo t through analysis of the levels of specific IgE (sIgE). Aká … This study was conducted to determine the sensitivity to Dermatophagoides pteronyssinus (Trouessart) and D. farinae Hughes with skin prick tests (SPT) and serologic tests in patients with allergic rhinitis (AR), and to specifically search for those mites in homes of patients. Conclusions: A clinical guideline was developed respecting particular methodology, validated by CMICA and COMPEDIA for its implementation among Mexican allergists. The clinical files of 279 patients. abundance in our samples, followed by family Chortoglyphidae. Although mites share the same taxonomic order, there are species antigenically distinct. External validation was obtained. Study period: January/2013–December/2016. We investigated the prevalence of house-dust mite sensitization by skin prick tests in each group. Diagnostic sensitivity values were: Dp, 79; Df, 84; Bt, 84 and B. kulagini, 83%. The three most frequent positive reactions were to DF (78%), DP (75%), and, unexpectedly, BT (77%). The percentage of asthmatics sensitized followed an age-dependent curve that began with the children under 6 years old (45.1%), reached its maximum between 12 and 19 years old (79.0%) and decreased to 25.8% in asthmatics older than 40 years. In Portugal, data on the role of Der p 1 and Der p 2 in patients with house dust mite (HDM) allergy are scarce. Conclusions. House dust and Musca domestica were separated into three peak fractions by gel filtration on Sephadex G-200. Les allergènes des acariens sont très étudiés. ャーダイアグノスティックス株式会社, Some products may not be available to you, and indications may differ from your region’s approved use. Contradictory results have been reported previously in the analyses of cross-reactivity among Blomia tropicalis (Blo t), Dermatophagoides pteronyssinus (Der p), and Dermatophagoides farinae (Der f). Nevertheless, most patients (58.6%) were polysensitized to the 3 species. Anaphylactic hypersensitivity is characterized by an exacerbated response involving the production of regulatory cytokines responsible for stimulating the production of IgE antibodies. Evaluation of sensitization to Der p 1 and Der p 2 in a pediatric population of the North of Portuga... House dust mites (Acari: Pyroglyphidae) in the cities of Gdańsk and Gdynia (Northern Poland). ... alergia alimentară, alergia la înţepături de insecte, alergia la latex. The value of Der p 1/Der p 2 correlated with the size of the prick-test papule, the value of the eosinophils and the total IgE.  |  This review criticizes, Previous investigations in alpine altitudes suggest a very low etiopathogenic relation between house-dust mites and bronchial asthma in these geographical zones. Vidal France vous informe qu'en naviguant sur ce site internet des cookies ayant une finalité de mesure de l’audience sont utilisés par Vidal France aux fins de produire des statistiques anonymes. source : Iglesias-Souto J et al : Oral mite anaphylaxis by Thyreophagus entomophagus in a child: a case report. Les mesures préventives contre les allergies aux dermatophagoides pteronyssinus consistent à réduire leur quantité pour descendre sous le seuil de déclenchement des symptômes. In total, 5,210 mites were isolated, 1,058 from the living rooms and 4,152 from the bedrooms, and the differences were statistically significant (P < 0.05). Inclusion criteria: 1) positive prick-test to D. pteronyssinus; and 2) clinically relevant disease under treatment. 2008 Aug;47(8):790-5. doi: 10.1111/j.1365-4632.2008.03657.x. Dermatophagoïdes farinae est le nom d'un des principaux acariens de maison et qui peut être à l'origine d'allergies. Ooreka accompagne vos projets du quotidien. The objective of this study was to compare living rooms and bedrooms, and woolen and spring mattresses in terms of the number and species of mites in houses in the province of Erzincan, Turkey. ... cei mai importanti din punct de vedere alergenic fiind cei denumiti Dermatophagoides pteronyssinus si Dermatophagoides farinae. Leverage state-of-the-art technology to develop precise antigen reagents resulting in highly accurate tests with excellent lot-to-lot quality. Objectives: The main objective of our work was studying the prevalence of cutaneous sensitization to Blomia kulagini and Blomia tropicalis in a population allergic to Dermatophagoides pteronyssinus living in the urban area of Cartagena for a minimum of two years. L'allergie débute généralement par une rhinite persistante (écoulement ou obstruction nasale, éternuements, démangeaisons du nez ou du palais, perte d'odorat), souvent associée à une conjonctivite (larmoiements, rougeurs ou picotements des yeux) ou à de la toux. Benemérita Universidad Autónoma de Puebla, Co‐sensitization and cross‐reactivity of Blomia tropicalis with two Dermatophagoides species in Guangzhou, China, Association of Cytokines in Individuals Sensitive and Insensitive to Dust Mites in a Brazilian Population. Results: One hundred and ten patients were included, withan age average of 24.1 years; 50% were males. Astazi, alergia este o problema recunoscuta, de proportii pandemice, afectand mai mult de 150 milioane de persoane numai in Europa. De nombreuses personnes sont allergiques aux acariens de poussière de maison (Dermatophagoides pteronyssinus, Dermatophagoides farinae ou Blomia tropicalis). Patients with D. farinae in their homes had 83.3% sensitivity to the species according to SPT, and 50% according to IgE.  |  Conclusions: More sophisticated studies are needed to elucidate if cutaneous sensitization to mites of genus Blomia is only an expression of cross-reactivity among several mites species; or, by opposite, it is a primary sensitization to theses mites and then they should be included in our routine diagnostic battery. Of them pyroglyphid mites produce IgE specific la Dermatophagoides farinae (d2) Laborator de analize. Allergenic components from Blomia tropicalis are important triggers of allergies in the tropics. A total of 254 patients were grouped as atopic and non-atopic according to sensitivity as evaluated by the Prick Test and to cytokine genotyping by the polymerase chain reaction-sequence specific primers (PCR-SSP) method using the Cytokine Genotyping Kit. Traitements de l'allergie aux acariens. Material and Methods: We have conducted an observational prospective study being the criteria for inclusion: living habitually in urban area of Cartagena for a minimum of two years, suffering symptoms compatible with rhinitis and/or bronchial asthma, and showing positive skin tests with D. pteronyssinus. Allergenic activities of these fractions which were measured by skin test and RAST were detected in two peaks of Fraction 1 and 3. The results of this study support the need to include the 3 allergens in diagnostic panels and for combined allergen-specific immunotherapy. Our results suggest a possible association between single nucleotide polymorphisms (SNPs) in cytokine genes and hypersensitivity to dust mites.

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